Original paper

Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity

Volume: 30, Issue: 1, Pages: 126662 - 126662
Published: Jan 1, 2020
Abstract
Starting from easy accessible pyrazoletetrahydropyran acetals, a series of new pyrazolone spirocyclohexadienone derivatives were synthesized and assayed for antitumor activity. Compound 10s was identified to possess good antitumor activity. It could induce MDA-MB-231 cancer cell apoptosis in a concentration dependent manner and arrest the cell cycle progression mainly at the G1...
Paper Details
Title
Discovery of pyrazolone spirocyclohexadienone derivatives with potent antitumor activity
Published Date
Jan 1, 2020
Volume
30
Issue
1
Pages
126662 - 126662
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