VISTA: A novel immunotherapy target for normalizing innate and adaptive immunity
Abstract
V-domain Ig suppressor of T cell activation (VISTA) is a novel checkpoint regulator with limited homology to other B7 family members. The constitutive expression of VISTA on both the myeloid and T lymphocyte lineages coupled to its important role in regulating innate and adaptive immune responses, qualifies VISTA to be a promising target for immunotherapeutic intervention. Studies have shown differential impact of agonistic and antagonistic...
Paper Details
Title
VISTA: A novel immunotherapy target for normalizing innate and adaptive immunity
Published Date
Apr 1, 2019
Journal
Volume
42
Pages
101308 - 101308
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