Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria

Like other severe systemic infections, malaria leads to stimulation of the HPA axis, resulting in increased GC levels. The essential roles of GCs for disease tolerance in malaria have been largely overlooked. GCs are decisive to survive malaria via the regulation and integration of vital systemic processes such as immune reactions, metabolism, and vascular function. Existing evidence of the function and possible dysregulation of the HPA axis in...