Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice

•APAP-induced acute liver injury is associated with hepatic VWF deposition. •APAP-induced acute liver injury is associated with elevation of VWF plasma levels. •VWF clearance is impaired in experimental APAP-induced acute liver injury. •VWF contributes to persistent platelet accumulation in the APAP-injured liver. •VWF deficiency or inhibition accelerates repair of the APAP-injured liver. Background & Aim Acetaminophen (APAP)-induced acute liver...