Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
Abstract
Sensitive and specific DNA hybridization is essential for nucleic acid chemistry. Competitive composition of probe and blocker has been the most adopted probe design for its relatively high sensitivity and specificity. However, the sensitivity and specificity were inversely correlated over the length and concentration of the blocker strand, making the optimization process cumbersome. Herein, we construct a theoretical model for competitive DNA...
Paper Details
Title
Thermodynamics and kinetics guided probe design for uniformly sensitive and specific DNA hybridization without optimization
Published Date
Oct 14, 2019
Journal
Volume
10
Issue
1
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