Transient Reprogramming of Neonatal Cardiomyocytes to a Proliferative Dedifferentiated State

Published: Oct 10, 2019
Abstract
Zebrafish and urodele amphibians are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through transient expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) transcription factors. Here, we utilized an OSKM-encoding non-integrating vector to induce transient...
Paper Details
Title
Transient Reprogramming of Neonatal Cardiomyocytes to a Proliferative Dedifferentiated State
Published Date
Oct 10, 2019
Journal
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