Evaluating the ion exchange chromatography for matrix-assisted PEGylation and purification of consensus interferon.

Volume: 67, Issue: 2, Pages: 196 - 205
Published: Mar 1, 2020
Abstract
Scientists have implemented protein-PEGylation technology for boosting-up the pharmacokinetics and stability of recombinant therapeutic proteins. In the present study, (a) matrix-assisted PEGylation was compared with solution-phase PEGylation and (b) matrix-assisted PEGylation was performed with different ion exchange resins for impact of chromatography medium on yield and purity of PEGylated product. DEAE Sepharose CL 6B, DEAE Fracto gel, and...
Paper Details
Title
Evaluating the ion exchange chromatography for matrix-assisted PEGylation and purification of consensus interferon.
Published Date
Mar 1, 2020
Volume
67
Issue
2
Pages
196 - 205
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