Production of potent long-lasting consensus interferon using albumin fusion technology in Pichia pastoris expression system
Abstract
Consensus interferon (cIFN) is a wholly synthetic therapeutic protein which is used to treat hepatitis C/B and certain types of malignancies. It has short serum half-life, therefore, to maintain its therapeutic level in the human body it requires thrice-weekly administration. Various strategies like PEGylation and micro-encapsulation have been developed during the last few years to enhance the pharmacokinetics of small therapeutic peptides. This...
Paper Details
Title
Production of potent long-lasting consensus interferon using albumin fusion technology in Pichia pastoris expression system
Published Date
Feb 1, 2020
Volume
166
Pages
105509 - 105509
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