Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.
Abstract
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II) have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased mass spectrometry with a motif deconvolution algorithm to profile and analyze a total of 99,265 unique peptides eluted from HLA-II molecules. We then trained an epitope prediction algorithm with these data and improved prediction of pathogen and tumor-associated class II...
Paper Details
Title
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.
Published Date
Oct 14, 2019
Journal
Volume
37
Issue
11
Pages
1283 - 1286
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