Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.

Volume: 37, Issue: 11, Pages: 1283 - 1286
Published: Oct 14, 2019
Abstract
Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II) have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased mass spectrometry with a motif deconvolution algorithm to profile and analyze a total of 99,265 unique peptides eluted from HLA-II molecules. We then trained an epitope prediction algorithm with these data and improved prediction of pathogen and tumor-associated class II...
Paper Details
Title
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.
Published Date
Oct 14, 2019
Volume
37
Issue
11
Pages
1283 - 1286
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