Pan-cancer analysis of clinical acquired resistance (AR) in BRAF-driven real-world cases
Abstract
Background null BRAF genomic alterations (GA) occur in multiple tumor types and BRAF/MEK targeted therapies are approved in melanoma and NSCLC. Diverse mechanisms of AR to these therapies have been proposed but have not been comprehensively assessed. null null null Methods null Hybrid-capture based comprehensive genomic profiling (CGP) was performed on FFPE (n = 228,629) or blood-based cell free DNA (cfDNA, n = 15,069) samples for 222,952...
Paper Details
Title
Pan-cancer analysis of clinical acquired resistance (AR) in BRAF-driven real-world cases
Published Date
Oct 1, 2019
Journal
Volume
30
Pages
v762 - v763
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