Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency

Pages: 791673
Published: Oct 4, 2019
Abstract
null Human cytomegalovirus (HCMV) latency is an active process which remodels the latently infected cell to optimise latent carriage and reactivation. This is achieved, in part, through the expression of viral genes, including the G-protein coupled receptor US28. Here, we use an unbiased proteomic screen to assess changes in host proteins induced by US28, revealing that interferon-inducible genes are downregulated by US28. We validate that MHC...
Paper Details
Title
Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency
Published Date
Oct 4, 2019
Journal
Pages
791673
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