Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy
Abstract
BRCA1/2 mutations and poly (ADP-ribose) polymerase (PARP) inhibitors are paradigmatic of synthetic lethal therapy. However, the activity of PARP inhibitors seems to vary considerably across BRCA1/2-mutant cancers and new insights into the tumour-lineage dependency of this synthetic lethal relationship might explain why BRCA1/2 mutations are not tumour-agnostic biomarkers of a response to PARP...
Paper Details
Title
Why BRCA mutations are not tumour-agnostic biomarkers for PARP inhibitor therapy
Published Date
Oct 3, 2019
Volume
16
Issue
12
Pages
725 - 726
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