Breast Cancer and the Environment: A Pilot Study of Nigerian Women

PURPOSE Breast cancer remains the leading cause of cancer in women throughout the world, and its incidence has been increasing markedly in Africa. Women of African ancestry not only develop breast cancer at earlier ages but also have more aggressive breast cancers, with higher prevalence of TP53 mutations and triple-negative breast cancer. Although environment-induced TP53 mutagenesis has been well described in liver and lung cancers, few...