EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A
Volume: 16, Issue: 3, Pages: 654 - 663
Published: Oct 29, 2019
Abstract
For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A (latent membrane protein) and hGM-CSF (human granulocyte/macrophage colony-stimulating factor) genes, was inserted into the pMV261 vector (secretory BCG plasmid). The expression levels of the...
Paper Details
Title
EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A
Published Date
Oct 29, 2019
Volume
16
Issue
3
Pages
654 - 663
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