Risk of CIN2 or more severe lesions after negative HPV‐mRNA E6/E7 overexpression assay and after negative HPV‐DNA test: Concurrent cohorts with a 5‐year follow‐up

Aim of this study was to compare the 5‐year risk of cervical intraepithelial neoplasia grade 2+ (CIN2+)/CIN3+ and the performance parameters at 3‐year rescreening of a negative E6/E7 mRNA‐human papillomavirus (HPV) test with those of a HPV‐DNA‐negative test. We studied a cohort of HPV‐negative women tested with the Aptima HPV‐mRNA Assay (“HPV‐mRNA cohort”) versus a cohort of HPV negatives tested with the Hybrid Capture 2 (HC2) DNA test living in...