Collisions on the Busy DNA Highway Set Up Barriers for Reprogramming

Why most cells remain refractory to transcription factor (TF)-induced fate conversion remains largely mysterious, with the answers holding important instructions on how to effectively direct cell identities. In this issue of Cell Stem Cell, Babos et al., 2019Babos K.N. Galloway K.E. Kisler K. Zitting M. Li Y. Shi Y. Quintino B. Chow R.H. Zlokovic B.V. Ichida J.K. Mitigating antagonism between transcription and proliferation allows...