Bringing Oncohistones into the Fold
Abstract
Summary: Identification of cancer-associated mutations in core histone genes has proved challenging due to these genes' highly conserved nature and presence in large arrays. Recent analyses of cancer genomes, including one in this issue of Cancer Discovery, show that mutations in the histone fold can affect nucleosome stability, providing a novel mechanism by which oncohistones contribute to tumorigenesis. See related article by Bennett et al.,...
Paper Details
Title
Bringing Oncohistones into the Fold
Published Date
Oct 1, 2019
Journal
Volume
9
Issue
10
Pages
1346 - 1348
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Notes
History