Tumour mutational burden and immune infiltrates in primary renal cell carcinoma and matched brain metastases

Background null High tumor mutational burden (TMB) as well as high density of tumor infiltrating lymphocytes (TIL) have been postulated as predictive response biomarkers for immune checkpoint inhibitor-based therapies. Therefore, we aimed to investigate the concordance of TMB and TIL in a series of primary/extracranial renal cell carcinoma specimens and matched brain metastases (BM). null null null Methods null Specimens from 10 patients with...