Extracellular pH and intracellular phosphatidylinositol 4,5-bisphosphate control Cl−currents in guinea pig detrusor smooth muscle cells

Abstract
Cl − channels serve as key regulators of excitability and contractility in vascular, intestinal, and airway smooth muscle cells. We recently reported a Cl − conductance in detrusor smooth muscle (DSM) cells. Here, we used the whole cell patch-clamp technique to further characterize biophysical properties and physiological regulators of the Cl − current in freshly isolated guinea pig DSM cells. The Cl − current demonstrated outward rectification...
Paper Details
Title
Extracellular pH and intracellular phosphatidylinositol 4,5-bisphosphate control Cl−currents in guinea pig detrusor smooth muscle cells
Published Date
Dec 1, 2019
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