Testosterone therapy induces molecular programming augmenting physiological adaptations to resistance exercise in older men

Background The andropause is associated with declines in serum testosterone (T), loss of muscle mass (sarcopenia), and frailty. Two major interventions purported to offset sarcopenia are anabolic steroid therapies and resistance exercise training (RET). Nonetheless, the efficacy and physiological and molecular impacts of T therapy adjuvant to short‐term RET remain poorly defined. Methods Eighteen non‐hypogonadal healthy older men, 65–75 years,...