Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy
Abstract
mtDNA is present in multiple copies in each cell derived from the expansions of those in the oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, paternal mtDNA leakage, and novel medical technologies aiming to prevent inheritance of mtDNA-linked diseases. Heteroplasmy phenotypic impact remains poorly understood. Mouse studies led to contradictory models of random drift or haplotype selection for...
Paper Details
Title
Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy
Published Date
Dec 1, 2019
Journal
Volume
30
Issue
6
Pages
1120 - 1130.e5
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