A clonal expression biomarker associates with lung cancer mortality
Abstract
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2-6. Here, we analyze multi-region whole-exome and RNA sequencing data for 156 tumor regions from 48 patients...
Paper Details
Title
A clonal expression biomarker associates with lung cancer mortality
Published Date
Oct 1, 2019
Journal
Volume
25
Issue
10
Pages
1540 - 1548
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