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Regional Adipose Compartments Confer Different Cardiometabolic Risk in Children and Adolescents:: The China Child and Adolescent Cardiovascular Health Study.

Published on Oct 1, 2019
· DOI :10.1016/J.MAYOCP.2019.05.026
Yinkun Yan4
Estimated H-index: 4
(Capital Medical University),
Yinkun Yan4
Estimated H-index: 4
(Capital Medical University)
+ 32 AuthorsLeina Jia1
Estimated H-index: 1
Abstract
Abstract Objective To investigate the associations of fat mass in specific regions with cardiometabolic risk factors in Chinese children and adolescents. Patients and Methods This cross-sectional study consisted of 8460 children and adolescents aged 6 to 18 years from Chinese urban areas who underwent dual-energy x-ray absorptiometry for regional fat masses and had cardiometabolic risk factors measured between January 1, 2013, and December 31, 2015. Results In the multivariate model containing arm fat mass, leg fat mass, and trunk fat mass, after adjustment for region, family income, age, puberty development, physical activity, and smoking, higher trunk fat mass was independently associated with greater odds of clustered cardiometabolic risk (odds ratio [OR], 2.21; 95% CI, 1.80-2.72), higher leg fat mass was associated with lower odds of clustered risk (OR, 0.72; 95% CI, 0.59-0.87), and arm fat mass was not significantly associated with clustered risk (OR, 1.22; 95% CI, 0.97-1.55). In the multivariate model including android fat mass, gynoid fat mass, and other covariates, higher android fat mass was positively associated with clustered risk (OR, 2.23; 95% CI, 1.88-2.64), but gynoid fat mass was not associated with clustered risk (OR, 0.86; 95% CI, 0.72-1.03). Analyses for individual risk factors demonstrated similar results. Conclusion Fat stored in different regions has differential influences on cardiometabolic risk in youth. Prospective studies are warranted to evaluate the long-term impacts of regional fat masses in childhood on cardiovascular risk in adulthood.
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References39
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#1Fangfang ChenH-Index: 1
Last. Jie Mi (Capital Medical University)H-Index: 6
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#1Yinkun Yan (Capital Medical University)H-Index: 4
#1Yinkun Yan (Capital Medical University)H-Index: 4
Last. Jie Mi (Capital Medical University)H-Index: 6
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Summary Obese children are at higher risk of being obese as adults, and adult obesity is associated with an increased risk of morbidity. This systematic review and meta-analysis investigates the ability of childhood body mass index (BMI) to predict obesity-related morbidities in adulthood. Thirty-seven studies were included. High childhood BMI was associated with an increased incidence of adult diabetes (OR 1.70; 95% CI 1.30–2.22), coronary heart disease (CHD) (OR 1.20; 95% CI 1.10–1.31) and a r...
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