Cilnidipine loaded transfersomes for transdermal application: Formulation optimization, in-vitro and in-vivo study

Cilnidipine, a BCS class II drug is a widely prescribed antihypertensive with poor oral bioavailability. An approach to deliver the drug as flexible vesicles called transfersomes through the skin was adopted to optimise the drug delivery. A quadratic model of Box-Behnken design was used as QbD approach to analyze the effect of variables on formulation quality (example: vesicle size, entrapment efficiency and transdermal flux). The optimized...