Type 3 Muscarinic Receptors (M3R) Contribute to Expulsion of Nippostrongylus brasiliensis Through Induction of Th2 Cytokines

Introduction: Lower rates of helminth infection in persons from developed countries are associated with a higher prevalence of autoimmune diseases including IBD (Weinstock & Elliott, 2009). In mice, infection with the enteric nematode Nippostrongylus brasiliensis (Nb) induces a Th2 cytokine response in small intestine (SI) and characteristic STAT6/IL-13 dependent changes in gut function including increased permeability, smooth muscle...