The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity

Upon activation naïve T cells undergo metabolic changes to form different subsets of effector or regulatory cells, and subsequently remodel their metabolic profile again to form memory. Interfering with these metabolic alterations leads to abrogation or reprogramming of T cell differentiation, demonstrating the importance of this pathway in T cell development. It has long been appreciated that the conversion of a healthy cell to a cancerous cell...