ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Abstract
TGFβ is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDA), yet inactivation of TGFβ pathway components occurs in only half of PDA cases. TGFβ cooperates with oncogenic RAS signaling to trigger epithelial-to-mesenchymal transition (EMT) in premalignant pancreatic epithelial progenitors, which is coupled to apoptosis owing to an imbalance of SOX4 and KLF5 transcription factors. We report that PDAs that develop with the TGFβ...
Paper Details
Title
ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer
Published Date
Jan 1, 2020
Journal
Volume
10
Issue
1
Pages
142 - 157
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