The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
Abstract
Post-transcriptional mechanisms have the potential to influence complex changes in gene expression, yet their role in cell fate transitions remains largely unexplored. Here, we show that suppression of the RNA helicase DDX6 endows human and mouse primed embryonic stem cells (ESCs) with a differentiation-resistant, "hyper-pluripotent" state, which readily reprograms to a naive state resembling the preimplantation embryo. We further demonstrate...
Paper Details
Title
The RNA Helicase DDX6 Controls Cellular Plasticity by Modulating P-Body Homeostasis
Published Date
Nov 1, 2019
Journal
Volume
25
Issue
5
Pages
622 - 638.e13
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