Matrix metalloproteinase-9 induces a pro-angiogenic profile in chronic lymphocytic leukemia cells
Abstract
Increased angiogenesis is commonly observed in chronic lymphocytic leukemia (CLL) tissues in correlation with advanced disease. CLL cells express pro- and anti-angiogenic genes and acquire a pro-angiogenic pattern upon interaction with the microenvironment. Because MMP-9 (a microenvironment component) plays important roles in solid tumor angiogenesis, we have studied whether MMP-9 influenced the angiogenic pattern in CLL cells....
Paper Details
Title
Matrix metalloproteinase-9 induces a pro-angiogenic profile in chronic lymphocytic leukemia cells
Published Date
Nov 1, 2019
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