Pyrococcus furiosus Argonaute-mediated nucleic acid detection
Abstract
We demonstrate that short single-stranded DNA generated by Pyrococcus furiosus Argonaute (PfAgo) can initiate a second round of cleavage. Based on this principle, we established a molecular diagnostic method, termed PfAgo-mediated Nucleic acid Detection (PAND). This method could detect DNA at attomolar sensitivities, distinguish single-nucleotide mutants and accomplish multiplexed...
Paper Details
Title
Pyrococcus furiosus Argonaute-mediated nucleic acid detection
Published Date
Jan 1, 2019
Journal
Volume
55
Issue
88
Pages
13219 - 13222
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