A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
Abstract
Aims Genome-wide association studies (GWAS) have consistently identified an association between coronary artery disease (CAD) and a locus on chromosome 10 containing a single gene, JCAD (formerly KIAA1462). However, little is known about the mechanism by which JCAD could influence the development of atherosclerosis. Methods and results Vascular function was quantified in subjects with CAD by flow-mediated dilatation (FMD) and vasorelaxation...
Paper Details
Title
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
Published Date
Oct 4, 2019
Journal
Volume
116
Issue
11
Pages
1863 - 1874
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