Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

Volume: 51, Issue: 4, Pages: 724 - 734.e4
Published: Oct 1, 2019
Abstract
•Identified ITS90.03, a monoclonal antibody that fully neutralizes SIVmac239•Crystalized fully glycosylated SIV gp120 with CD4 and ITS90.03•The ITS90 lineage targets a hole in the SIVmac239 glycan shield•The SIV-glycan shield functionally resembles its HIV counterpart HIV- and SIV-envelope (Env) trimers are both extensively glycosylated, and antibodies identified to date have been unable to fully neutralize SIVmac239. Here, we report the...
Paper Details
Title
Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields
Published Date
Oct 1, 2019
Journal
Volume
51
Issue
4
Pages
724 - 734.e4
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