Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer
Abstract
MAD2 is an intriguing protein, which has been associated with poor survival in cancer. Depending on the organ-specific cancer, either high expression or low expression levels have been correlated with low survival rates in patients. MAD2 is also a marker of contradiction. The normal function of MAD2 is to accumulate at kinetochores and generate a wait signal preventing the cell from progressing to anaphase of the cell cycle until the spindle...
Paper Details
Title
Too MAD or not MAD enough: The duplicitous role of the spindle assembly checkpoint protein MAD2 in cancer
Published Date
Jan 1, 2020
Journal
Volume
469
Pages
11 - 21
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