Integrated genomic profiling expands clinical options for patients with cancer.
Abstract
Genomic analysis of paired tumor–normal samples and clinical data can be used to match patients to cancer therapies or clinical trials. We analyzed 500 patient samples across diverse tumor types using the Tempus xT platform by DNA-seq, RNA-seq and immunological biomarkers. The use of a tumor and germline dataset led to substantial improvements in mutation identification and a reduction in false-positive rates. RNA-seq enhanced gene fusion...
Paper Details
Title
Integrated genomic profiling expands clinical options for patients with cancer.
Published Date
Sep 30, 2019
Journal
Volume
37
Issue
11
Pages
1351 - 1360
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Notes
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