Outstanding Issues with Umbrella and Basket Studies

Identification of actionable oncogenic drivers has changed the treatment landscape of NSCLCs. Large-scale tumor sequencing has uncovered a number of aberrations in putative oncogenic genes, which have been seen as targets for cancer therapy. To efficiently test drugs targeting protein products of these putative oncogenes, multiarm trials have been designed over the last few years. The two most common trial designs are umbrella trials and basket...