Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial–Mesenchymal Transition

Published on 2019in International Journal of Molecular Sciences4.18
· DOI :10.3390/ijms20194813
Sevindzh Kletukhina , Olga Neustroeva + 2 AuthorsMarina O. Gomzikova3
Estimated H-index: 3
Epithelial–mesenchymal transition (EMT) is a process that takes place during embryonic development, wound healing, and under some pathological processes, including fibrosis and tumor progression. The molecular changes occurring within epithelial cells during transformation to a mesenchymal phenotype have been well studied. However, to date, the mechanism of EMT induction remains to be fully elucidated. Recent findings in the field of intercellular communication have shed new light on this process and indicate the need for further studies into this important mechanism. New evidence supports the hypothesis that intercellular communication between mesenchymal stroma/stem cells (MSCs) and resident epithelial cells plays an important role in EMT induction. Besides direct interactions between cells, indirect paracrine interactions by soluble factors and extracellular vesicles also occur. Extracellular vesicles (EVs) are important mediators of intercellular communication, through the transfer of biologically active molecules, genetic material (mRNA, microRNA, siRNA, DNA), and EMT inducers to the target cells, which are capable of reprogramming recipient cells. In this review, we discuss the role of intercellular communication by EVs to induce EMT and the acquisition of stemness properties by normal and tumor epithelial cells.
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#1Chia-Chia Chao (FJU: Fu Jen Catholic University)H-Index: 2
#2Chia Chia Chao (FJU: Fu Jen Catholic University)
Last.Yi Chen Yang (National Taichung University of Science and Technology)H-Index: 1
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#1Drenka Trivanović (University of Belgrade)H-Index: 10
#2J. Krstic (University of Belgrade)H-Index: 73
Last.Juan F. Santibanez (University of Belgrade)H-Index: 23
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#1Marina O. Gomzikova (Kazan: Kazan Federal University)H-Index: 3
#2Sevindzh Kletukhina (Kazan: Kazan Federal University)
Last.Albert A. Rizvanov (Kazan: Kazan Federal University)H-Index: 20
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#1Henrieta Škovierová (Comenius University in Bratislava)H-Index: 13
#2Terézia Okajčeková (Comenius University in Bratislava)H-Index: 1
Last.Erika Halasova (Comenius University in Bratislava)H-Index: 14
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