Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat
Abstract
Adeno-associated virus vectors (rAAV) are currently the most common vehicle used in clinical trials of retinal gene therapy, usually delivered through subretinal injections to target cells of the outer retina. However, targeting the inner retina requires intravitreal injections, a simple and safe procedure, which is effective for transducing the rodent retina, but still of low efficiency in the eyes of primates. We investigated whether adjuvant...
Paper Details
Title
Retina transduction by rAAV2 after intravitreal injection: comparison between mouse and rat
Published Date
Sep 27, 2019
Journal
Volume
26
Issue
12
Pages
479 - 490
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