P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles
Abstract
Physiological or pathological muscle disuse/inactivity or loss of the neural-muscular junction cause muscle atrophy. Atrophy-inducing conditions cause metabolic oxidative stress in the muscle tissue, activation of the ubiquitin-proteasome and of the autophagosome-lysosome systems, enhanced removal of the damaged proteins and organelles, and loss of muscle mass and strength. The signaling pathways that control these catabolic processes are only...
Paper Details
Title
P38α MAPK coordinates the activities of several metabolic pathways that together induce atrophy of denervated muscles
Published Date
Oct 22, 2019
Journal
Volume
287
Issue
1
Pages
73 - 93
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