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Common brain disorders are associated with heritable patterns of apparent aging of the brain

Published on Oct 1, 2019in Nature Neuroscience21.126
· DOI :10.1038/s41593-019-0471-7
Karolinska Schizophrenia1
Estimated H-index: 1
(Oslo University Hospital),
Tobias Kaufmann23
Estimated H-index: 23
(Oslo University Hospital)
+ -2 AuthorsLars T. Westlye53
Estimated H-index: 53
(University of Oslo)
Sources
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. Using structural MRI data from 45,615 individuals aged 3–96 years, Kaufmann and colleagues reveal that common brain disorders are associated with heritable patterns of apparent aging of the brain.
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