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Common brain disorders are associated with heritable patterns of apparent aging of the brain

Published on 2019in Nature Neuroscience21.13
· DOI :10.1038/s41593-019-0471-7
Tobias Kaufmann20
Estimated H-index: 20
(Oslo University Hospital),
Karolinska Schizophrenia1
Estimated H-index: 1
(UM: Maastricht University)
+ 9 AuthorsLars T. Westlye46
Estimated H-index: 46
(University of Oslo)
Abstract
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3–96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders. Using structural MRI data from 45,615 individuals aged 3–96 years, Kaufmann and colleagues reveal that common brain disorders are associated with heritable patterns of apparent aging of the brain.
  • References (45)
  • Citations (3)
References45
Newest
#1Eli A. Stahl (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 48
#2Gerome Breen ('KCL': King's College London)H-Index: 53
Last.Héléna A. Gaspar ('KCL': King's College London)H-Index: 14
view all 277 authors...
#1Thomas Wolfers (Radboud University Nijmegen)H-Index: 9
#2Nhat Trung Doan (Oslo University Hospital)H-Index: 13
Last.Lars T. Westlye (University of Oslo)H-Index: 46
view all 11 authors...
#1Jonathan Marchini (University of Oxford)H-Index: 54
#2Clare Bycroft (University of Oxford)H-Index: 3
Last.Peter Donnelly (University of Oxford)H-Index: 91
view all 18 authors...
#1James H. ColeH-Index: 20
#2Stuart J. Ritchie (Edin.: University of Edinburgh)H-Index: 23
Last.Qian Zhang (UQ: University of Queensland)H-Index: 36
view all 18 authors...
Cited By3
Newest
#1Martina J. Lund (University of Oslo)H-Index: 4
#2Dag Alnæs (University of Oslo)H-Index: 14
Last.Tobias Kaufmann (University of Oslo)H-Index: 20
view all 0 authors...
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