Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H

Volume: 130, Issue: 1, Pages: 189 - 202
Published: Nov 18, 2019
Abstract
Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRSS1 were linked to the development of HP. Here, we developed a mouse model by inserting a full-length human PRSS1R122H gene, the most commonly mutated...
Paper Details
Title
Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H
Published Date
Nov 18, 2019
Volume
130
Issue
1
Pages
189 - 202
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