The Value of Progression-Free Survival as a Treatment End Point Among Patients With Advanced Cancer

Importance

It is unclear whether patients with advanced cancer value surrogate end points, particularly progression-free survival (PFS). Despite this uncertainty, surrogate end points form the basis of regulatory approval for the majority of new cancer treatments.

Objective

To summarize and qualitatively assess studies evaluating whether patients with advanced cancer understand and value PFS.

Evidence Review

MEDLINE,...