Human γδ T‐cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation

Background Although γδ T cells comprise up to 10% of human peripheral blood T cells, questions remain regarding their role in disease states and T‐cell receptor (TCR) clonal expansions. We dissected anti‐viral functions of human γδ T cells towards influenza viruses and defined influenza‐reactive γδ TCR s in the context of γδ‐ TCR s across the human lifespan. Methods We performed 51 Cr‐killing assay and single‐cell time‐lapse live video...