Frontal Contribution to Hippocampal Hyperactivity During Memory Encoding in Aging
Abstract
Hippocampal hypo- as well as hyper-activation have been reported during memory encoding in older individuals. Prefrontal cortex provides top-down state signals to the hippocampus that bias its computation during memory encoding and retrieval, and disturbed top-down signals could contribute to hippocampal hyper-activation. Here we used > 500 cross-sectional and longitudinal observations from a face-name encoding-retrieval fMRI task to examine...
Paper Details
Title
Frontal Contribution to Hippocampal Hyperactivity During Memory Encoding in Aging
Published Date
Sep 25, 2019
Volume
12
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