Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region

E74‐like factor 5 ( ELF5 ) and ETS‐homologous factor ( EHF ) are epithelial selective ETS family transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic fibrosis (CF) lung disease severity. EHF controls many key processes in lung epithelial function so its regulatory mechanisms are important. Using CRISPR/Cas9 technology, we removed three key cis ‐regulatory elements (CREs) from the chr11p13 region and also...