Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
Abstract
A series of 4-trifluoromethyl pyrazoles have been prepared via the copper-catalyzed cycloaddition of 2-bromo-3,3,3-trifluoropropene with a variety of N-arylsydnone derivatives under mild conditions. This new protocol under optimized reaction conditions [Cu(OTf)2/phen, DBU, CH3CN, 35 °C] afforded 4-trifluoromethyl pyrazoles in moderate to excellent yields with excellent...
Paper Details
Title
Copper-catalyzed chemoselective synthesis of 4-trifluoromethyl pyrazoles
Published Date
Jan 1, 2019
Journal
Volume
9
Issue
53
Pages
30952 - 30956
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