52 A PHENOME-WIDE ASSOCIATION AND MENDELIAN RANDOMISATION STUDY OF POLYGENIC RISK FOR DEPRESSION IN UK BIOBANK

Obesity is a clinically relevant and highly prevalent somatic comorbidity of major depression (MDD). Genetic predisposition and history of childhood trauma have both independently been demonstrated to act as risk factors for obesity and to be associated with alterations in reward related brain structure and function. We therefore aimed to investigate the influence of childhood maltreatment and genetic risk for obesity on structural and...