Ischemic Stroke and Systemic Embolism in Warfarin Users With Atrial Fibrillation or Heart Valve Replacement Exposed to Dicloxacillin or Flucloxacillin

The antibiotics dicloxacillin and flucloxacillin induce cytochrome P450‐dependent metabolism of warfarin. We explored the influence of these drug–drug interactions on the clinical effectiveness of warfarin therapy due to atrial fibrillation or heart valve replacement. Using the population‐based Danish registers, we performed a propensity‐score matched cohort study including around 50,000 episodes of dicloxacillin/flucloxacillin matched to...