O.31Proteomic profiling unravels a key role of CD74, CD163 and STAT1 in sporadic inclusion body myositis

Inclusion body myositis is a chronic muscle-specific disease of adulthood leading to progressive paresis and swallowing difficulties. Muscle biopsy reveals a severe myopathic/dystrophic process with a complex inflammatory infiltrate and presence of protein deposits. Despite the characteristic clinical picture and well-known biopsy findings, the pathogenesis of sIBM is still elusive and not fully understood. In the current study, we applied...