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Dietary n-3 polyunsaturated fatty acids, fish intake and healthy ageing

Published on Dec 1, 2019in International Journal of Epidemiology7.339
· DOI :10.1093/ije/dyz196
Esther García-Esquinas16
Estimated H-index: 16
(UAM: Autonomous University of Madrid),
Rosario Ortolá1
Estimated H-index: 1
(UAM: Autonomous University of Madrid)
+ 2 AuthorsFernando Rodríguez Artalejo70
Estimated H-index: 70
(UAM: Autonomous University of Madrid)
Abstract
BACKGROUND: Seafood consumption and dietary intake of n-3 polyunsaturated fatty acids (PUFA) protect from cardiovascular disease, muscle wasting and mortality; however, their role in delaying unhealthy ageing is uncertain. METHODS: A prospective cohort study with 1592 community-dwelling individuals aged ≥60 years recruited in 2008-2010, and followed through 2015. Intake of seafood and n-3 PUFA [eicosapentanoic acid (EPA) and docosahexanoic acid (DHA)] was estimated using a validated diet history and food composition tables. Unhealthy ageing was assessed across the domains of physical and cognitive function, mental health, morbidity, self-rated health and vitality. RESULTS: Higher blue fish consumption was negatively associated with unhealthy ageing in 2015 [multivariate s (95% confidence interval) per interquartile range (IQR) increase of fish: -0.49 (-0.90; -0.08)] and, specifically, was associated with lower accumulation of functional impairments [-1.00 (-1.71; -0.28)] and morbidities [-0.30 (-0.73; 0.13)]. Individuals with high intakes of EPA (≥0.47 g/day) and DHA (≥0.89 g/day) presented the highest reductions in age-related deficits accumulation: -1.61 (-3.01; -0.22) and -1.34 (-2.76; 0.08), respectively. Intake of EPA and DHA were negatively associated with the accumulation of functional deficits [results per IQR increase: -0.79 (-1.64; -0.06) and -0.84 (-1.67; -0.01), respectively] and morbidities [-0.60 (-1.10; -1.11) and -0.60 (-1.09; -0.11)]. No associations were observed between n-3 PUFA and self-rated or mental health, or between white fish and unhealthy ageing. CONCLUSIONS: In this cohort of Spanish individuals with elevated intake of fish and a high adherence to the Mediterranean diet, consumption of blue fish and n-3 PUFA had a prospective protective association with deficits accumulation.
  • References (58)
  • Citations (1)
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References58
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#1Rosario Ortolá (UAM: Autonomous University of Madrid)H-Index: 3
#1Rosario Ortolá (UAM: Autonomous University of Madrid)H-Index: 1
Last. Esther López-García (UAM: Autonomous University of Madrid)H-Index: 39
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Abstract Background Animal and vegetable-based proteins differ on their effect on many health outcomes, but their relationship with unhealthy aging is uncertain. Thus, we examined the association between changes in animal and vegetable protein intake and unhealthy aging in older adults. Methods Data came from 1951 individuals aged ≥ 60 years recruited in the Seniors-ENRICA cohort in 2008 − 2010 (wave 0) and followed-up in 2012 (wave 1), 2015 (wave 2) and 2017 (wave 3). Dietary protein intake was...
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#1Luana T. Rossato (UFU: Federal University of Uberlandia)H-Index: 3
#2Brad J. Schoenfeld (Lehman College)H-Index: 25
Last. Erick P. de Oliveira (UFU: Federal University of Uberlandia)H-Index: 4
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#1Juliana Lustosa Torres (UFRJ: Federal University of Rio de Janeiro)
#2Silvia Lanziotti Azevedo da Silva (Universidade Federal de Alfenas)H-Index: 4
Last. Luciana A. C. Machado (UFMG: Universidade Federal de Minas Gerais)H-Index: 11
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#1Lucía Arias-Fernández (UAM: Autonomous University of Madrid)H-Index: 1
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Abstract Objectives To analyze sex- and education-specific trajectories of health deficits accumulation (DA) throughout old age and to examine whether these trajectories differ according to health domains. Design Population-based prospective cohort study. Setting and participants: In Spain, 3228 community-dwelling individuals aged 60 years or older were followed up for 10 years. Measures At baseline and 3 follow-up visits, a DA index (0 to 100% deficit) was calculated based on the number and sev...
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#1Pan Zhuang (ZJU: Zhejiang University)H-Index: 3
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#1Magnus Bäck (KI: Karolinska Institutet)H-Index: 31
#2Göran K. Hansson (KI: Karolinska Institutet)H-Index: 96
Although a high marine food intake is considered cardioprotective, randomized trials of ω-3 fatty acids initially generated conflicting results in terms of the role of ω-3 supplementation in cardio...
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#1JoAnn E. Manson (Harvard University)H-Index: 235
#2Nancy R. Cook (Harvard University)H-Index: 107
Last. Julie E. Buring (Harvard University)H-Index: 155
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Abstract Background Higher intake of marine n−3 (also called omega-3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether supplementation with n−3 fatty acids has such effects in general populations at usual risk for these end points is unclear. Methods We conducted a randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (at a dose of 2000 IU per day) and marine n−3 fatty acids (at a d...
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Abstract Background Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride levels, but data are needed to determine its effects on ischemic events. Methods We performed a multicenter, randomized, double-blind, placebo-controlled trial involving patients with established cardiovascular disease or with diabetes and other risk factors, who had been receiving statin therapy and wh...
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#1Isabel Rodríguez-Sánchez (UAM: Autonomous University of Madrid)H-Index: 1
#2Esther García-Esquinas (UAM: Autonomous University of Madrid)H-Index: 16
Last. Fernando Rodríguez Artalejo (UAM: Autonomous University of Madrid)H-Index: 70
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Background: the association between pain characteristics and frailty risk is uncertain. Objective: to investigate the separate impact of the frequency, intensity and location of pain on frailty risk and its possible mechanisms. Methods: prospective cohort of 1505 individuals ≥63 years followed between 2012 and 2015 in Spain. In 2012, pain was classified into: lowest pain (Score 0), middle pain (Score 1-4) and highest pain (Score 5-6). Incident frailty was assessed in 2015 as having ≥3 Fried crit...
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#1Amin GasmiH-Index: 1
#2Pavan Kumar Mujawdiya (BITS: Birla Institute of Technology and Science)H-Index: 1
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