A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Volume: 28, Issue: 2, Pages: 253 - 263
Published: Sep 26, 2019
Abstract
Insights into individual differences in gene expression and its heritability (h2) can help in understanding pathways from DNA to phenotype. We estimated the heritability of gene expression of 52,844 genes measured in whole blood in the largest twin RNA-Seq sample to date (1497 individuals including 459 monozygotic twin pairs and 150 dizygotic twin pairs) from classical twin modeling and identity-by-state-based approaches. We estimated for each...
Paper Details
Title
A characterization of cis- and trans-heritability of RNA-Seq-based gene expression
Published Date
Sep 26, 2019
Volume
28
Issue
2
Pages
253 - 263
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